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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLK1
All Species:
31.82
Human Site:
Y445
Identified Species:
43.75
UniProt:
P53350
Number Species:
16
Phosphosite Substitution
Charge Score:
0.19
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53350
NP_005021.2
603
68255
Y445
D
S
T
R
L
I
L
Y
N
D
G
D
S
L
Q
Chimpanzee
Pan troglodytes
XP_001163623
603
68223
Y445
D
S
T
R
L
I
L
Y
N
D
G
D
S
L
Q
Rhesus Macaque
Macaca mulatta
XP_001092070
603
68240
Y445
D
S
T
R
L
I
L
Y
N
D
G
D
S
L
Q
Dog
Lupus familis
XP_547091
832
93293
Y673
D
S
T
R
L
I
L
Y
N
D
G
D
S
L
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q07832
603
68282
Y445
D
S
T
R
L
I
L
Y
N
D
G
D
S
L
Q
Rat
Rattus norvegicus
Q62673
603
68295
Y445
D
S
T
R
L
I
L
Y
N
D
G
D
S
L
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505317
482
55166
D325
T
R
L
I
M
Y
N
D
G
D
S
L
Q
Y
I
Chicken
Gallus gallus
NP_001025810
595
66904
Y436
D
S
T
R
L
I
M
Y
N
D
G
D
S
L
Q
Frog
Xenopus laevis
P70032
598
68193
Y439
D
S
T
R
L
I
M
Y
N
D
G
D
S
L
Q
Zebra Danio
Brachydanio rerio
NP_001003890
595
67743
C436
D
S
T
R
L
I
M
C
A
D
G
D
S
L
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52304
576
66955
G405
Y
S
D
K
Y
G
F
G
Y
Q
L
C
D
E
G
Honey Bee
Apis mellifera
XP_396707
575
66141
D417
G
V
G
V
M
F
N
D
G
T
R
L
I
M
L
Nematode Worm
Caenorhab. elegans
P34331
649
73615
A450
S
R
I
M
L
D
Q
A
G
N
E
L
T
Y
I
Sea Urchin
Strong. purpuratus
XP_784826
587
66895
H426
D
S
T
R
L
L
L
H
A
N
A
D
T
L
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P0C8M8
626
70215
G467
N
R
G
Q
V
L
S
G
N
E
V
W
V
K
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STV4
445
50410
D288
D
V
Y
A
A
F
D
D
P
E
E
Q
T
Y
A
Baker's Yeast
Sacchar. cerevisiae
P32562
705
81013
L548
N
G
T
T
V
L
R
L
A
D
A
E
E
F
W
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.8
69.5
N.A.
95
94.1
N.A.
69.3
80
79.7
74.3
N.A.
50.7
51.4
49.9
59.3
Protein Similarity:
100
99.8
99.8
71
N.A.
97.6
96.8
N.A.
74.7
89.8
90.5
87.5
N.A.
69.4
69.9
66.2
76.4
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
93.3
93.3
80
N.A.
6.6
0
6.6
53.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
100
100
86.6
N.A.
13.3
13.3
20
86.6
Percent
Protein Identity:
N.A.
31.7
N.A.
26
33.9
N.A.
Protein Similarity:
N.A.
50.1
N.A.
40.4
51.6
N.A.
P-Site Identity:
N.A.
6.6
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
46.6
N.A.
20
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
6
6
0
0
6
18
0
12
0
0
0
6
% A
% Cys:
0
0
0
0
0
0
0
6
0
0
0
6
0
0
0
% C
% Asp:
65
0
6
0
0
6
6
18
0
65
0
59
6
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
12
12
6
6
6
6
% E
% Phe:
0
0
0
0
0
12
6
0
0
0
0
0
0
6
0
% F
% Gly:
6
6
12
0
0
6
0
12
18
0
53
0
0
0
6
% G
% His:
0
0
0
0
0
0
0
6
0
0
0
0
0
0
0
% H
% Ile:
0
0
6
6
0
53
0
0
0
0
0
0
6
0
12
% I
% Lys:
0
0
0
6
0
0
0
0
0
0
0
0
0
6
6
% K
% Leu:
0
0
6
0
65
18
42
6
0
0
6
18
0
59
6
% L
% Met:
0
0
0
6
12
0
18
0
0
0
0
0
0
6
0
% M
% Asn:
12
0
0
0
0
0
12
0
53
12
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
6
0
0
0
0
0
0
% P
% Gln:
0
0
0
6
0
0
6
0
0
6
0
6
6
0
53
% Q
% Arg:
0
18
0
59
0
0
6
0
0
0
6
0
0
0
0
% R
% Ser:
6
65
0
0
0
0
6
0
0
0
6
0
53
0
0
% S
% Thr:
6
0
65
6
0
0
0
0
0
6
0
0
18
0
0
% T
% Val:
0
12
0
6
12
0
0
0
0
0
6
0
6
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
6
0
0
6
% W
% Tyr:
6
0
6
0
6
6
0
48
6
0
0
0
0
18
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _